Advanced Technology in Neurosurgery by L. I. Malis (auth.), Prof. Franco Pluchino M.D., Prof.

By L. I. Malis (auth.), Prof. Franco Pluchino M.D., Prof. Giovanni Broggi M.D. (eds.)

Technological advancements in neurosurgery are disussed. using surgical lasers, ultrasound aspirators, bipolar coagulator and operative microscopes for surgical procedure of deep-seated neoplasms and vascular malformations is mentioned. Intraoperative tracking, chronotherapy, continual neurostimulation and stereotactic interstitial irradiation are coated and symptoms for interventional neuroradiology are reviewed.

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5: 5-14 Application of the Argon Laser in Neurosurgery Y. HosoBucHI An argon ion surgical laser system (Model 770 AMPL, Cooper Medical Corporation, Mountain View, California) has been used in our department since 1981. 5 nm; approximately 80% of the power output is available at these wavelengths. The laser is coupled to the operating microscope via a fiberoptic micromanipulator delivery system. Transmission through the fiberoptic cables results in a rather homogeneous distribution of energy within the laser beam.

McCulloch et al. (1984) have also reported one patient who developed cerebral edema following the administration of ISO joules/ cm 2 of red light 48h after the injection of Smg/kg of HpD. As suggested by EI-Far and Dimstone (1984) and Dougherty (1984) the use of a more pure preparation of HpD or a different porphyrin such as uroporphyrin-I may limit or eventually eliminate at least the skin toxicity. Analysis of the Drug-Light Interaction The action mechanism in photoradiation therapy and in dye-sensitized photo-oxidation reactions for both in vitro and in vivo systems has been an area of avid research from which some understanding of the basic processes involved has developed.

2% saline. Thus far, there has been no toxicity associated with the administration of HpD in this manner. , Raritan, NJ). The absorption spectrum of HpD consists of 5 bands extending from the nearultraviolet to the red (Fig. 2). In parallel with the initial clinical investigations, a number of laboratory experiments were performed. These utilized both cell culture models of human and experimental brain tumors and an animal model of malignant ENU-induced brain tumors in rats. These experiments have confirmed HpD photodynamic cytotoxicity for brain tumor cells at practical concentrations of HpD and achievable doses of light.

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