Advances in combination therapy for asthma and COPD by Jan Lotvall

By Jan Lotvall

content material: Similarities and adjustments within the pathophysiology of bronchial asthma and COPD / Christian Virchow --
Glucocorticoids : pharmacology and mechanisms / Peter Barnes --
Inhaled corticosteroids? medical results in bronchial asthma and COPD / Paul O'Byrne --
LABAS : pharmacology, mechanisms and interplay with anti inflammatory remedies / Gary Anderson --
lengthy and ultra-long appearing beta-2-agonists / Mario Cazzola --
the security of long-acting beta agonists and the advance of mix cures for bronchial asthma and protracted obstructive pulmonary disorder / Eugene Bleecker --
Inhaled blend treatment with glucocorticoids and long-acting beta-2-agonists in bronchial asthma and COPD, present and destiny views / Jan Lotvall --
Novel anti inflammatory remedies for bronchial asthma and COPD / Ian Adcock --
Novel biologicals on my own and together in bronchial asthma and allergic reaction / William Busse --
Anti-infective remedies in bronchial asthma and COPD / Jonathan D.R. Macintyre & Sebastian L. Johnston --
lengthy performing muscarinic antagonists in bronchial asthma and COPD / Denis O'Donnell --
Phosphodiesterase inhibitors in obstructive lung illness / Jan Lotvall --
organic remedies in improvement for COPD / Riccardo Polosa --
Triple therapy?, within the administration of persistent obstructive lung ailment (COPD). the worth of mix remedy with inhaled steroid, lengthy appearing anticholinergicbronchodilator and lengthy performing beta 2 agonist bronchodilator in COPD / Ronald Dahl.

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Barnes PJ, Adcock IM, Ito K. Histone acetylation and deacetylation: importance in inflammatory lung diseases. Eur Respir J 2005;25:552–63. 9. Adcock IM, Ford P, Barnes PJ, Ito K. Epigenetics and airways disease. Respir Res 2006;7:21. P1: OTA/XYZ JWST083-02 P2: ABC JWST083-L¨otvall 34 September 8, 2011 0:41 Printer Name: Yet to Come CHAPTER 2 10. Ito K, Barnes PJ, Adcock IM. Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits IL-1␤-induced histone H4 acetylation on lysines 8 and 12.

Barnes PJ. Transcription factors in airway diseases. Lab Invest 2006;86:867–72. 7. Kouzarides T. Chromatin modifications and their function. Cell 2007;128:693–705. 8. Barnes PJ, Adcock IM, Ito K. Histone acetylation and deacetylation: importance in inflammatory lung diseases. Eur Respir J 2005;25:552–63. 9. Adcock IM, Ford P, Barnes PJ, Ito K. Epigenetics and airways disease. Respir Res 2006;7:21. P1: OTA/XYZ JWST083-02 P2: ABC JWST083-L¨otvall 34 September 8, 2011 0:41 Printer Name: Yet to Come CHAPTER 2 10.

6 Acetylation of glucocorticoid receptors (GR). Binding of a corticosteroid to GR results in its acetylation by histone acetyltransferases (HAT), such as CREB-binding protein (CBP), and a dimer of acetylated GR then binds to glucocorticoid response elements (GRE) to activate or suppress genes (such as side effect genes). Deacetylation of GR by histone deacetylase-2 (HDAC2) is necessary for GR to interact with CBP and inhibit nuclear factor-␬B (NF-␬B) to switch off inflammatory genes. GM-CSF, granulocyte-macrophage colony stimulating factor; IL-8, interleukin-8; SLPI, secretory leukoprotease inhibitor.

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