Allergens and allergen immunotherapy by Richard F. Lockey, Dennis K. Ledford

By Richard F. Lockey, Dennis K. Ledford

Modernized and up-to-date, Allergens and Allergen Immunotherapy, Fourth Edition discusses all significant parts of allergens and immunotherapies:

  • pollens
  • animal/insect
  • fungi
  • food
  • the manufacture and standardization of allergen vaccines
  • the management of vaccines
  • the avoidance and remedy of difficult effects

Compiling the learn of an influential staff of investigators and scientists, Allergens and Allergen Immunotherapy is full of speedy reference charts, tables and indexes. Allergists, immunologists, and otolaryngologists will locate this new streamlined fourth variation a good sensible reference for on-the-go prognosis, remedy, and administration of allergies.


  • new specialise in the main suitable info regarding allergens and immunotherapy
  • new concise chapters for simpler use as a regular reference
  • the new innovative approach to sublingual swallow immunotherapy is totally discussed
  • describes inhaled, ingested, and injected allergens
  • allergen vaccines from formula to fabricate to administration
  • details the avoidance and remedy for hostile effects
  • covers allergen vaccines from formula to fabricate to administration

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Additional info for Allergens and allergen immunotherapy

Sample text

Med Clin North Am 1921; 5:751. 57. Boatner CH, Efron BG. Studies with antigens. XII. Preparation and properties of concentrates of house dust allergen. J Invest Dermatol 1942; 5:7. 58. Cooke RA. Human sensitization. J Immunol 1916; 1:201. 59. Stull A, Cooke RA, Tenant J. The allergen content of protein extracts; its determination and deterioration. J Allergy 1933; 4:455. 60. Thommen AA. The specific treatment of hay fever. In: Coca AF, Walzer M, Thommen AA, eds. Asthma and Hay Fever in Theory and Practice.

Med Clin North Am 1923; 7:605. 108. Zoss AR, Koch CA, Hirose RS. Alum-ragweed precipitate: Preparation and clinical investigation; preliminary report. J Allergy 1937; 8:829. 109. Stull A, Cooke RA, Sherman WB et al. Experimental and clinical studies of fresh and modified pollen extracts. J Allergy 1940; 11:439. 110. Naterman H. The treatment of hay fever by injections of suspended pollen tannate. J Allergy 1941; 12:378. 111. Rockwell G. Preparation of a slowly absorbed pollen antigen. Ohio State Med J 1941; 37:651.

An immune-mediated blocking of histamine was postulated through injections of a histamine-linked antigen [(histamine-azo-depreciated horse serum) hapamine] to induce antihistamine antibodies (190). While some of these modalities were initially encouraging, later studies failed to confirm their benefit. Favorable symptomatic improvements of empirical but nonspecific, treatment designed to modulate immune functions could not be determined without controlled clinical trials. The use of these agents fell by the wayside as new scientific knowledge of mechanisms of allergy were acquired (191).

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